Commit c19d3f53 authored by levintow's avatar levintow
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Updating readme on the repo

parent ce94efc4
---
title: "AIDS Clinical Trial Group (ACTG) Study Dataset"
author: "Sara Levintow"
date: "10/6/2017"
date: "`r Sys.Date()`"
output: md_document
---
# AIDS Clinical Trial Group (ACTG) Study Dataset #
......
AIDS Clinical Trial Group (ACTG) Study Dataset
==============================================
The ACTG study 320 compared a combination of three antiretroviral drugs
against a pair.
The AIDS Clinical Trials Group (ACTG) 320 compared a combination of
three antiretroviral drugs (two nucleoside analogues, zidovudine and
lamivudine, plus a protease inhibitor, indinavir) against a pair
(zidovudine and lamivudine alone). The dataset consists of 1,156
HIV-positive patients enrolled in the trial between January 29, 1996 and
January 27, 1997. At screening, all patients had a CD4 cell count ≤200
cells per cubic millimeter, at least 3 months of prior zidovudine
therapy, and no previous treatment with lamivudine or protease
inhibitors. Patients were stratified based on CD4 count (≤50 vs. 51-200)
and randomly assigned to the three-drug or two-drug regimen. The outcome
of interest was the occurrence of AIDS or death, and the findings from
the trial were reported in Hammer's 1997 paper in the New England
Journal of Medicine. Trial participants were followed until AIDS
diagnosis, death, loss to follow-up, or administrative censoring.
Covariates measured at baseline and available in the dataset are age,
sex, race, ethnicity, Karnofsky score, CD4 cell count, and history of
injection drug use.
### Installation
......@@ -18,11 +33,11 @@ You can install the package from Bitbucket
- male: 1=male, 0=female
- black: 1=black, 0=non-black
- hispanic: 1=hispanic, 0=non-hispanic
- idu: numeric variable for exposure (1=history of injection drug use,
0=no history)
- idu\_f: factor variable for exposure (1=history of injection drug
use, 0=no history)
- art: 1=triple therapy, 0=double therapy
- idu: 1=history of injection drug use, 0=no history of injection drug
use
- art: 1=triple therapy, 0=dual therapy
- art\_f: factor variable for treatment group (1=triple therapy,
0=dual therapy)
- r: 1=in subcohort, 0=not
- age: years of age at randomization
- karnof: Karnofsky score (100=normal, 0=dead)
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